Assessment of Nephroprotective Activity of PippalyadiAgad on Diclofenac Sodium Induced Nephrotoxicity in Albino Mice: An Experimental Study

Background: Nephrotoxicity due to Diclofenac Sodium can be correlated with this concept of Dushi Visha and nephroprotective drugs mentioned in Ayurveda texts may play an important role area. Pippalyadi Agad is the herbo-mineral medication stated by Yogaratnakara for treatment Visha. Some formulation have shown efficacy correcting nephrotoxicity. Objective: To study activity on diclofenac sodium induced nephrotoxicity albino mice. Methods: The experimental was carried out mice as per CPCSEA guidelines after getting approval from Institutional Animal Ethics Committee (IAEC). 30 mice, each weighing about 20-30 gm, were procured Bharat serum vaccines. housed institutional animal house standard conditions. equally divided into five groups having six animals group Trial Drug (low dose), (medium Standard Control, Disease Control Vehicle Control. For assessment nephrotoxicity, monitored Day 0, 15 45 carrying blood investigations such BUN, Serum Creatinine, Body weight CBC. Data subjected appropriate statistical tests derive results. Results: at low medium doses significantly lowered BUN Creatinine comparison 45. (p < 0.001 p 0.001) increased body weights No significant difference CBC parameters observed any Groups except Group Conclusion: has based biochemical changes